1. Jordan Weinstein
  2. Case Discussions
  3. Thursday, 28 July 2016

We are looking after a 29 year-old man with history of hypertension. Presents with severe hypertension, anuric renal failure with creatinine 1200 umol/L and severe pulmonaryhaemorrhage.

His ANCA, anti-GBM, C3, C4, ANA and rhematoid factor are all normal. ADAM-TS activity 55%. Cryglobulins are pending.

Preliminary renal biopsy shows TMA.

He has received has 5 sessions of PLEX, plus 3 pulses of corticosteroids with no response to date.

Can you suggest what you might do at this point?

Dr. Jordan Weinstein

About Us

Thrombotic microangiopathy (TMA) is a group of rare disorders affecting the microvasculture of most organ beds. The impact of these diseases on those affected by them is immense. Our understanding of these disorders is rapidly expanding and therapeutic options are beginning to appear. However, many challenges remain when managing TMA and one is a practical one: the diseases are rare and the experts in them are few and spread worldwide. Read more...